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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.0 g/kg bodyweight during the acute phase and 1.6 g/kg to 2.4 g/kg bodyweight during the maintenance phase (Table 2). The increase for the maintenance phase was of comparable magnitude to the increase for the acute phase. Discussion We have shown that ostarine supplementation can exert an anabolic effect on the body, resulting in increases in free testosterone, bioavailable testosterone, free testosterone/dHT and total LBM in human healthy males. This effect is due to its ability to potentiate LBM as demonstrated in this study and is an important aspect of the anabolic effect of ostarine. A recent study showed a robust increase of testosterone (1.3 mg/dl) after ostarine treatment in older men compared to placebo (Burgundy et al, 2010, 2011). However, the present study demonstrates that these changes are not dependent on age, and can be induced in young (10-12yrs old), elderly (>90yrs old) and trained (30-40kg person) male participants by a single dose of ostarine. This effect is more pronounced from ostarine than from testosterone in the elderly (Table 2). Our data show that ostarine decreases bioavailable testosterone in older men, as compared to placebo. There is a trend for bioavailable testosterone to decrease in both males and females, and a dose effect was noted in both sexes. In the present study, we observed a dose-dependent decrease in bioavailable testosterone in the elderly with the highest values (1.7% reduction) observed in the 10-12yrs age group. This would have resulted in decreased bioavailable testosterone with increasing age and might be related to the fact that the bioactive dose of ostarine in our study was 1.8 g/kg bodyweight. Bioavailable testosterone is the amount of testosterone that can be obtained from the body over time, and is the most important factor to be controlled in the dosage of testosterone and the corresponding duration of therapy, which should in turn be closely studied in these elderly populations. Although, our data show that bioavailable testosterone is still significantly less than 0.9 ng/ml (the cutoff level for testosterone deficiency), the current prevalence of testosterone deficiency has been documented to be around 1% (Lai et al, 1997) which is within the range of our data and thus, we believe this value should be used to limit the effectiveness of ostarine supplementation. However, our data show that o Related Article: